Crp
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Clinical Significance of C-reactive Protein
This book explores the latest developments in the field the acute phase protein (APP), C-reactive protein or CRP in different diseases, highlighting the structural and functional aspects of CRP in disease biology. Divided into 5 sections, the book examines important topics such as the role of CRP in neurodegenerative, cardiac and parasitic diseases, as well as in cancer and inflammatory bowel disease, and the expression of CRP in pediatric respiratory diseases. In addition it discusses the clinical role of CRP in diagnostics and therapeutics, sepsis, ICU and ITU patients, and also as a primary marker for inflammation. Given its scope, this book will appeal to scholars in various fields of medicine and biology.
Community Series in Biology of C-reactive Protein, volume II
C-reactive protein (CRP) serves as a critical biomarker in inflammatory conditions, synthesized predominantly by the liver in response to inflammatory cytokines. Despite its pivotal role in the innate immune system and being a subject of study for nearly a century, definitive functions of CRP in inflammation remain elusive. Further complexity is introduced as CRP exhibits versatility in binding to phosphocholine and activating the complement system, suggesting variant forms with potentially distinct biological activities. Recent inquiries into structure-function relationships and comparative studies across species underline the necessity for deeper examination into CRP's roles across various physiological and pathological contexts. This Research Topic aims to comprehensively explore CRP gene expression mechanisms, the structural and functional dynamics of CRP across the animal kingdom, and its applications in understanding and managing infectious and non-infectious diseases and inflammation. A thorough grasp of CRP biology is crucial for the development of innovative therapeutic strategies targeting this protein to treat various inflammatory disorders effectively. To elucidate the broad implications of CRP in health and disease, we invite contributions that encompass a range of studies focused on: - Functions of CRP in diverse inflammatory conditions including autoimmune, infectious, cardiovascular, and neurodegenerative diseases - Detailed analysis of CRP's structure-function relationships - Complement activation by CRP and its complexes - Potential of CRP as a therapeutic agent or a target for new treatments - Diagnostic and therapeutic roles of serum CRP levels in inflammatory diseases - CRP's involvement in COVID-19 - Regulatory mechanisms of CRP gene expression in varied states - Evolutionary aspects of CRP and its role in the primitive immune system - Comparative studies on CRP homologs including SAP and PTX3 We welcome a variety of article formats, including Original Research, Review, and more, aiming to fuse molecular biology with clinical insights to shape future research and treatment paradigms. Article types and fees This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description: Brief Research Report Case Report Classification Clinical Trial Editorial FAIR² Data FAIR² DATA Direct Submission General Commentary Hypothesis and Theory ... View all formats Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Biology of C-reactive Protein
C-reactive protein (CRP) is a component of the innate immune system. CRP is synthesized by the liver in response to pro-inflammatory cytokines and the biosynthesis of CRP increases dramatically during acute inflammation. CRP is considered to be a non-specific serum biomarker for inflammatory diseases. The functions of CRP during the inflammatory state, however, have not been defined yet.
